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Together, the couple had ten children, three of which died at a young age. Of the seven children that lived, three were infertile Darwin thoroughly recorded the status of his health and the health of his family.

Image Source: Genetics and Beyond. Researchers looked at four generations of Darwin and Wedgwood families and discovered many consanguineous marriages on both sides.

By All That's Interesting. Among the Bedouin it can happen that a paternal male cousin can lodge a complaint after the marriage has taken place, compelling the father to reimburse the bride price or have the marriage annulled.

If the paternal male cousin cannot marry his paternal female cousin immediately due to financial or other considerations, the paternal male cousin can also "reserve" her by making a public and formal statement of his intentions to marry her at a future date.

A more distant relative acquires priority to marry a girl over her paternal male cousin by reserving her soon after her birth In Egypt cousin marriage may have been even more prevalent than in Arabia in past periods, with one source from the s observing that it was common among Egyptian Arabs and native Egyptian Muslims in villages within Egypt but less so in Cairo where first cousin marriage accounts 35 percent of marriages in Cairo than in other parts of Egypt.

Reportedly the husband and wife would continue to call each other "cousin" because the tie of blood was seen as indissoluble while the marriage was not.

In the upper and middle classes the young man was seldom allowed to see the face of his female cousin after she reached puberty.

Cousin marriage was also practiced in the Sinai Peninsula , where a girl is sometimes reserved by her cousin with money long before puberty, and among Bedouins in the desert between the Nile and the Red Sea.

Cousin marriage was practiced in Medina during Muhammad's time, but out of recorded marriages in one sample only 15 were between abnaa 'amm or paternal cousins of any degree.

Cousin marriages are decreasing among Iranians. Since the Pahlavi era less Iranians has practised cousin marriages.

Additionally, the proportion of cousin marriage among urban families stayed constant: it was only rural families that drove the increase.

For all periods the proportion of cousin marriage among highly educated women was somewhat lower than among uneducated women.

It is hypothesized that decreases in infant mortality during the period may have created a larger pool of eligible cousins to marry. This is usually done to preserve wealth in the family and is more common in rural areas.

Among the Jews of Iraq, if the cousin cannot be persuaded to forgo his rights, then he is paid a sum of money by the girl's father.

Among the Kurdish Hamawand tribe the paternal male cousin must give his consent for the marriage to take place, though in the southern Kurdish regions the cousin right is not as strongly emphasized.

Among Arabs and Berbers in Morocco [15] the cousin right has also traditionally prevailed. Patai states in his other book The Myth of the Jewish Race that percentage of cousin marriage among Jews varies extensively with geographic location.

Among Israeli Ashkenazi Jews , who originate mainly from Europe, the first-cousin marriage rate was measured in a study at 1.

But among non-Ashkenazim the first-cousin marriage rate was 8. Thus a total The highest frequencies of cousin marriages were found among Jews from Iraq High rates were also found among couples from Yemen Jews from Egypt, Syria, Lebanon, and Turkey saw rates of 7— A later —70 study rated the first-cousin marriage rate among Ashkenazim at 0.

Cousin marriage is common among the Kababish tribe of the Sudan. In Syria the right belongs to the paternal male cousin alone and the maternal male cousin [ clarification needed ] has no special rights.

The custom is however less frequent in big cities such as Damascus and Aleppo. Patai reports that in the decades preceding the right was often ignored among the Syrian urban middle class.

Among the upper classes it appeared to be again more common, as certain leading families protected their wealth and status by reserving daughters for their cousins, though sons had more freedom of choice.

This situation was also loosening at the time of Patai's work. This holds also among the Syrian Turks and Kurds.

But the Syrian Circassians hold cousin marriage absolutely forbidden, similar to the Circassians of the Caucasus. Cousin marriage rates were higher among women, merchant families, and older well-established families.

Marriage patterns among the elite were, however, always diverse and cousin marriage was only one option of many. Rates were probably lower among the general population.

In Turkey the rate of consanguineous marriage is 8. Social and cultural factors are especially important in marriages between first and second cousins.

The highest rate of consanguineous marriage can be found in South Eastern and Eastern Anatolia regions of Turkey due to a significant Kurdish population.

In the South Palestinian village of Artas in the s, of marriages 35, or In the oasis-village of Sidi Khaled, some miles south of Algiers, among the Mzabites further south, among the Chaamba , and among the Moors of the extreme western Sahara, cousin marriage is preferred.

Based in Dubai , United Arab Emirates , it indicates that Arab countries have among the highest rates of genetic disorders in the world.

Some pathologies are endemic to the Arab states, including thalassaemia , Tourette's syndrome , Wilson's disease , Charcot-Marie-Tooth disease , mitochondrial encephalomyopathies and Niemann-Pick disease.

Several organizations maintain genetic databases for each Arabic country. At present, the CTGA database is centrally maintained in Dubai, and hosts entries for nearly Mendelian disorders and related genes.

This number is increasing as researchers are joining the largest Arab scientific effort to define genetic disorders described in the region.

The Center promotes research studies on these emergent disorders. The Centre provide information about specific countries, [4] and maintain a list of Genomic diseases.

Specific rare autosomal recessive diseases are high in Arabic countries like Bardet Biedl syndrome , Meckel syndrome , congenital chloride diarrhea , severe childhood autosomal recessive muscular dystrophy SMARMD Lysosomal storage diseases and PKU are high in the Gulf states.

Dr Teebi's book provides detailed information and by country. Forty of them - more than half - have died. But MERS is not yet a pandemic, could become pervasive in genetic disease patient.

Dr Thurman' guidebook about Rare genetic diseases [10] another book Arabic genetic disorders layman guide [11] Saudi Journal article about genetic diseases in Arabic countries [12] The highest proportion of genetic disorders manifestations are: congenital malformations followed by endocrine metabolic disorders and then by Neuron disorders such as Neuromotor disease and then by blood immune disorders and then neoplasms.

The Mode of Inheritance is mainly autosomal recessive followed by autosomal dominant. Some of the diseases are beta-thalassemia mutations, sickle-cell disease, congenital heart-disease, glucosephosphate dehydrogenase deficiency, alpha-thalassemia , molecular characterization, recessive osteoperosis, gluthanione-reducatsafe DEf.

A study about sickle cell anemia in Arabs [13] article about Birth defects [14] 6Glucose Phisphate isomere deficiency responsible for unexpected hemolytic episodes.

Diagnosis of genetic disorders after birth is done by clinicians, lab tests, and sometimes genetic testing. Genetic testing profiling screening of pregnant women's fetuses for List of disorders included in newborn screening programs using Microchip Genetic Microarrary might help detect genetic mutations incompatible with life and determining abortion.

Some genetic tests of born children might help finding the right treatment. Most of the genetic markers of Arabs genetic diseases are phenotypic i.

Even though genetic mutations of Gulf states are mostly the same, but some genetic phenotypes are Kuwaiti etc.

The diseases have geographical distribution among Arab countries such as greater Syria, Gulf states, Yemen, Western block Morocco, Algeria, Tunisia , because of the restricted marriages to each block or even to one country.

Moreover, cousin marriages conseigenity and endogamy marriages restricted to minority sects excaberate the problem.

Distancing of marriages from distant gene pools might help resolve the problem in Arabic countries. Many of the pronounced genetic deficiencies in Arabs are located on HLA segment on chromosome 6.

This same segment mutations are markers of Arabs in Genealogical and forensic profiling tests and studies. The Maternal ancestral lineages of Arabic countries are very diverse.

Many of the genetic disorders specific to Arabs are located on HLA segment on chromosome 6. These same segment mutations are also markers of Arabs in genealogical and forensic profiling tests and studies.

The Arabian component is the main autosomal element in the Gulf region. It is most closely associated with local Arabic-speaking populations.

The Levantine component is the main autosomal element in the Near East and Caucasus.

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